![]() ![]() Endothelium-dependent vasodilation without insulin was not changed in either of the two treatment groups. Treatment with carvedilol did not change insulin-stimulated endothelial function. Insulin-stimulated endothelial function was deteriorated after treatment with metoprolol, the percentage change in forearm blood-flow was 60.19% ± 17.89 (at the highest serotonin dosages) before treatment and -33.80% ± 23.38 after treatment (p = 0.007). Vaso-reactivity studies were done before and after the two-month treatment period. ![]() Insulin-stimulated endothelial function was assessed after co-infusion of insulin for sixty minutes. Endothelium-dependent vasodilation was assessed by using venous occlusion plethysmography with increasing doses of intra-arterial infusions of the agonist serotonin. MethodĢ4 patients with type 2 diabetes were randomized to receive either 200 mg metoprolol succinate or 50 mg carvedilol daily. The aim of this study was to examine the effect of metoprolol versus carvedilol on endothelial function and insulin-stimulated endothelial function in patients with type 2 diabetes. Studies of beta blockade in patients with type 2 diabetes have shown inferiority of metoprolol treatment compared to carvedilol on indices of insulin resistance. ![]()
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